Welcome to Clarksville!

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Clarksville, MO is located on Missouri Highway 79 which is part of the Great River Road and is one of the most scenic highways along the Mississippi River. It overlooks U.S. Lock and Dam 24, providing a close vantage point to view all river boat and barge traffic. This City, located in Pike County, is also one of the largest winter migrating areas for the Bald Eagle. Clarksville is filled with artists, potters, glass blowers, jewelry designers, antique dealers, furniture makers, and specialty craftsmen.

Clarksville, MO is on a National Scenic Byway and lies halfway between Canada and the Gulf of Mexico, halfway between Hannibal and St. Louis, MO and is near the Clarence Cannon Dam and Mark Twain Lake. It rests at the foot of Lookout Point/Sky Lift Hill, the top of which affords an 800 square mile view of the river and valley and is one of the highest points on the Mississippi River.

Pike County was the childhood home of Mrs. Albert P. Greensfelder, the wife of the St. Louis civic leader who was the originator of the Great River Road from Canada to the Gulf of Mexico.

With the historic Mark Twain lore of Hannibal, the beautiful homes and estates in the Louisiana and Clarksville areas of Pike County, the first Missouri Capitol and Old Town area of St. Charles, and the numerous attractions of the St. Louis scene, Clarksville offers its’ own unique place on an incomparable route for travel.